Hough returned to the show, although the pair were ultimately eliminated in the Semifinals Competition.
In the film, which chronicles a small-town girl (Aguilera) who finds success at a Los Angeles burlesque club, Hough plays a dancer named Georgia.
In 2016, she played Sandy in the live Fox television production of Grease. Hough was one of the Million Dollar Dancers in the 2006 ABC game show called Show Me the Money. On November 27, 2007, Hough and her partner, three-time Indianapolis 500 champion Hélio Castroneves, became the winners of season five.
She left London that year, after having been "abused, mentally, physically, everything," she said, a situation that escalated "when I started hitting puberty, when I started becoming a woman and stopped being a little girl. I was told if I ever went back to the United States, three things were going to happen. Hough returned for season six with radio host/comedian Adam Carolla, but they were eliminated in week four.
In July 2008, Hough was nominated at the 60th Primetime Emmy Awards in the category of "Outstanding Choreography" for her Mambo "Para Los Rumberos" (performed with partner Hélio Castroneves) on Dancing with the Stars.
On August 25, 2008, the cast of season seven was announced, and Hough was partnered with Hannah Montana actor Cody Linley.
Auditions were also held to recruit a new group of dancers to join the Hough's, although some back-up dancers from the previous year returned.
On July 9, 2016, the Hough's held a free fitness pop-up event called 'Move Interactive' in Los Angeles, which they announced would be the first of many to come.
The event started off in Sherman Oaks with a workout session at Pulse Fitness Studios led by celebrity personal trainer and owner, Mark Harari.
The participants then took part in a 2-mile run along Ventura Blvd, before finishing off with a dance fitness class at Just Dance Los Angeles. She later signed with Universal Music Group Nashville's Mercury Nashville division.
She felt abdominal pains during their jitterbug performance on October 27, 2008 and was immediately rushed to a hospital following the encore performance.
She subsequently had surgery to have her appendix removed, causing her to miss several performances; Edyta Śliwińska stood in for her.
On November 20, 2008, Hough told Ryan Seacrest on his radio show she would not be returning to Dancing with the Stars, for the foreseeable future, in order to further her music career.